学術論文 - 田中宏昌研究室

2025年度

1. A. Miyazaki, T. Taki, K. Nakamura, M. Ogawa-Momohara, H. Tanaka, M. Hori, K. Ebisawa and M. Akiyama

Low-temperature plasma-activated Ringer's lactate solution induces apoptosis in melanoma cells by downregulating heat shock proteins and by inducing mitochondrial dysfunction

JournalofDermatologicalScience, 121, 48～55, 2026

2. T. Yamakawa, K. Inoue, K. Ishikawa, M. Hori and H. Tanaka

Long-Term Dynamics of Nitric Oxide Radicals in Plasma-Activated Ringer's Lactate Solution

PlasmaProcessesandPolymers, 23, 2026

3. S. Toyokuni, Y. Y. Kong, Y. Maeda, Q. Lyu, Y. Ohara, K. Sato, Y. Motooka, K. Nakamura and H. Tanaka

Ferroptosis and cancer: when iron turns against tumors

CellularandMolecularLifeSciences, 83, 2025

4. Koki Ono, Ayako Tanaka, Kenji Ishikawa, Wakana Takeuchi, Kenichi Uehara, Shigeo Yasuhara, Masaru Hori and Hiromasa Tanaka*

The Effect of Electrical Stimulation on the Cellular Response of Human Mesenchymal Stem Cells Grown on Silicon Carbide-Coated Carbon Nanowall Scaffolds

Bioengineering, 12, 1073～1073, 2025

5. Du Liyin; Miron Camelia; Du Xizhuo; Mizuno Masaaki; Toyokuni Shinya; Kajiyama Hiroaki; HORI Masaru; Tanaka Hiromasa

Differential cytotoxicity of plasma-treated arginine in breast cancer and normal cell lines: time-dependent effects and media-driven modulation

JournalofAppliedPhysics, 64, 097002～097002, 2025

6. Tatsuhiro Esaki, Akane Suzuki, Yukino Shinozaki, Kenichi Nomura, Yuki Kagawa, Maho Yamada, Kae Nakamura, Hiromasa Tanaka, Shinya Toyokuni, Masaru Hori, Masaaki Mizuno

Effect of Non-Thermal Plasma on the Interface Between Skin and Surface Electrodes for Biological Signal Measurement

PlasmaProcessesandPolymers, 22, e70081, 2025

7. R. Sakai, K. Ishikawa, H. Kondo, K. Niitsu, M. Hiramatsu, H. Tanaka and M. Hori

Platinum nanoparticle-decorated carbon nanowall anodes fabricated via top-down approach for abiotic glucose fuel cells

ScientificReports, 15, 2025

8. Y. Ito, M. Kanda, H. Tanaka, K. Nakamura, M. Mizuno, M. Hori, H. Kajiyama and Y. Kodera

Antitumor effects of plasma-activated sodium acetate solution on gastric cancer cells

ScientificReports, 15, 2025

9. C. Miyamoto, Y. Yoshino, H. Tanaka, H. Hara, S. Endo and A. Ikari

Plasma-activated medium disrupts intercellular barrier function in HaCaT cells by suppressing claudin-1 expression via clathrin-dependent endocytosis

Biochim Biophys Acta Gen Subj, 1869, 130826, 2025

2024年度

1. Swathy Jayaprasad, Arun Kumar Dhasiyan, Naohiro Shimizu, Osamu Oda, Hiromasa Tanaka and Masaru Hori

Radical enhanced growth of GaN on Si with the buffer layer of GaN at a low temperature of 600 °C

JournalofCrystalGrowth, 128089, 2024

2. K. Sato, H. Tanaka, Y. Okazaki, M. Hori, H. Hibi, S. Toyokuni

New era of plasma dentistry

FreeRadicalResearch, 58, 868-874, 2024

3. Taishi Yamakawa, Ayako Tanaka, Camelia Miron, Kae Nakamura, Hiroaki Kajiyama, Shinya Toyokuni, Masaaki Mizuno, Masaru Hori & Hiromasa Tanaka

Effects of autophagy on the selective death of human breast cancer cells exposed to plasma-activated Ringer’s lactate solution

FreeRadicalResearch, 5, 758～769, 2024

4. Liyin DU, Camelia MIRON, Takashi KONDO, Jun KUMAGAI, Masaaki MIZUNO, Shinya TOYOKUNI, Hiroaki KAJIYAMA, Masaru HORI, Hiromasa TANAKA

Selective killing of human breast cancer cells by plasma-treated L-arginine solution

PlasmaProcessesandPolymers, 22, 2400192, 2024

5. H. Tanaka, K. Ishikawa, S. Toyokuni

Low-temperature plasma as a strategy to achieve SDGs

FreeRadicalResearch, 58, 594～595, 2024

6. Hiroshi Hashizume, Hidemi Kitano, Hiroko Mizuno, Akiko Abe, Shih-Nan Hsiao, Genki Yuasa, Satoe Tohno, Hiromasa Tanaka, Shogo Matsumoto, Hitoshi Sakakibara, Eisuke Kita, Yoji Hirosue, Masayoshi Maeshima, Masaaki Mizuno & Masaru Hori

Direct plasma treatment of caryopses after flowering in brewer’s rice cultivar Yamadanishiki enhanced those grain qualities through “Smart Agriculture System”

ScientificReports, 14, 29454, 2024

7. Yoshihiro Sakamoto, Takayoshi Tsutsumi, Hiromasa Tanaka, Kenji Ishikawa, Hiroshi Hashizume, Masaru Hori

High-Speed Removal Process for Organic Polymers by Non-Thermal Atmospheric-Pressure Spark Discharge at Room Temperature and Its Mechanism

Coatings 2024, 14, 1339, 2024

8. Camelia Miron, Bianca Andreica, Manuela M. Iftime, Adrian Fifere, Taishi Yamakawa, Shinya Toyokuni, Masaaki Mizuno, Liliana M. Tartau, Andrei Bejan, Yashiro Motooka, Takashi Kondo, Ion Sava, Valeria Harabagiu, Jun Kumagai, Ayako Tanaka, Hiromasa Tanaka, Luminita Marin, Masaru Hori

Cold plasma irradiation of chitosan: A straight pathway to selective antitumor therapy

International Journal of Biological Macromolecules, 281, 136513, 2024

9. Camelia Miron, Hiromasa Tanaka, Nikolay Britun, Hiroshi Hashizume, Kenji Ishikawa, Du Liyin, Taishi Yamakawa, Yuya Kurebayashi, Takashi Kondo, Hiroki Kondo, Hiroaki Kajiyama, Shinya Toyokuni, Masaaki Mizuno, Masaru Hori

Cold Atmospheric Pressure Plasma-Activated Liquids for Cancer Treatment

Advances in Digital Health and Medical Bioengineering, 150～162, 2023

10. Hiromasa Tanaka, Masaaki Mizuno, Kenji Ishikawa, Camelia Miron,Yasumasa Okazaki, Shinya Toyokuni, Kae Nakamura, Hiroaki Kajiyama, Masafumi Ito, Masaru Hori

Science and Applications of Plasma-Activated Solutions: Current Trends and Future Directions

PlasmaMedicine, 1, 67 – 76, 2024

11. Junichi Usuda, Kenshin Yagyu, Hiromasa Tanaka, Masaru Hori, Kenji Ishikawa and Takahashi Yasufumi

Nanoscale visualization of the anti-tumor effect of a plasma-activated Ringer’s lactate solution

FaradayDiscussions, 257, 212~223, 2024

2023年度

1. Li Jiang, Hao Zheng, Moe Ishida, Qinying Lyu, Shinya Akatsuka, Yashiro Motooka, Kotaro Sato, Yoshitaka Sekido, Kae Nakamura, Hiromasa Tanaka, Kenji Ishikawa, Hiroaki Kajiyama, Masaaki Mizuno, Masaru Hori, Shinya Toyokuni

Elaborate cooperation of poly(rC)-binding proteins 1/2 and glutathione in ferroptosis induced by plasma-activated Ringer's lactate.

Free Radic Biol Med, 214, 28～41, 2024

2. Naoyuki Iwata , Kenji Ishikawa, Yasuhiro Nishikawa, Hiroyuki Kato, Motoyuki Shimizu, Masashi Kato, Hiromasa Tanaka, Masafumi Ito, Masaru Hori

Oxygen radical irradiation transforms an organic fertilizer l-tryptophan into an environment and human-friendly bactericide

EnvironmentalTechnology&Innovation33(2024)103496, 33, 103496, 2023

3. Hiroaki Eguchi, Yaqing Yu, Yuta Yoshino, Hirokazu Hara, Hiromasa Tanaka, Akira Ikari

Plasma-activated medium ameliorates the chemoresistance of human lung adenocarcinoma cells mediated via downregulation of claudin-2 expression

, 2023

4. Kotaro Sato, Ming Yang, Kae Nakamura, Hiromasa Tanaka, Masaru Hori, Miki Nishio, Akira Suzuki, Hideharu Hibi, Shinya Toyokuni

Ferroptosis induced by plasma-activated Ringer's lactate solution prevents oral cancer progression

Oral Dis, 30, 3912～3924., 2023

5. Manuela-Maria Iftime, Gabriela Liliana Ailiesei, Sergiu Shova, Camelia Miron, Hiromasa Tanaka, Masaru Hori, Luminita Marin

New betulin imine derivatives with antioxidant and selective antitumor activity

New J. Chem, 47, 16551, 2023

6. TAKASHI KONDO, HIROSHI HASHIZUME, HIROMASA TANAKA, KENJI ISHIKAWA, JUN-ICHI SAITOH MASARU HORI

The Possibility of Cancer Therapy with a Combination of Low Temperature Plasma and Hyperthermia

ThermalMed, 39, 21～30, 2023

7. Yasumasa Okazaki, Jun Yoshitake, Nanami Ito, Kanako Sasaki, Hiromasa Tanaka, Masaru Hori, Takahiro Shibata, Shinya Toyokuni

Tetrachloroaurate (III)–induced oxidation increases nonthermal plasma-induced aldehydes

, 2023

8. Kenji Ishikawa, Keigo Takeda, Shinji Yoshimura, Takashi Kondo, Hiromasa Tanaka, Shinya Toyokuni, Kae Nakamura, Hiroaki Kajiyama, Masaaki Mizuno, and Masaru Hori

Generation and measurement of low-temperature plasma for cancer therapy: a historical review

, 2023

9. Hiroshi Hashizume, Hidemi Kitano, Hiroko Mizuno, Akiko Abe, Genki Yuasa, Satoe Tohno, Hiromasa Tanaka, Kenji Ishikawa, Shogo Matsumoto, Hitoshi Sakakibara, Yoji Hirosue, Masayoshi Maeshima, Masaaki Mizuno, and Masaru Hori

Efficacy of periodic cold plasma treatment in a paddy to produce white-core grains in brewer’s rice cultivar Yamadanishiki

, 2023

10. Camelia Miron, Kenji Ishikawa, Satoshi Kashiwagura, Yang Liu, Daiki Ito, Yuki Suda, Yugo Hosoi, Hiroshi Hashizume, Hiroki Kondo, Hiromasa Tanaka, Kae Nakamura, Hiroaki Kajiyama, Shinya Toyokuni, Massaki Mizuno, and Masaru Hori

Cancer-specific cytotoxicity of Ringer’s acetate solution irradiated by cold atmospheric pressure plasma

, 2023

2022年度

1. K. Sato, K. Fujii, H. Tanaka, M. Hori, H. Hibi, S. Toyokuni

Exposure of low-temperature plasma after vaccination in tongue promotes systemic IgM induction against spike protein of SARS-CoV-2

FreeRadicalResearch, 2023

2. S. Toyokuni, H. Zheng, Y. Kong, K. Sato, K. Nakamura, H. Tanaka, Y. Okazaki,

Low-temperature plasma as magic wand to differentiate between the good and the evil

FreeRadicalResearch, 2023

3. H. Tanaka, D. Iwata, Y. Shibata, T. Hase, D. Onoshima, N. Yogo, H. Shibata, M. Sato, K. Ishikawa, I. Nagasawa, Y. Hasegawa, M. Ishii, Y. Baba, M. Hori

High-performance glass filters for capturing and culturing circulating tumor cells and cancer-associated fibroblasts

ScientificReports, 13, 2023

4. H. Tanaka, M. Mizuno, K. Ishikawa, C. Miron, Y. Okazaki, S. Toyokuni, K. Nakamura, H. Kajiyama, M. Hori

Plasma activated Ringer’s lactate solution

FreeRadicalResearch, 2023

5. Y. Liu, K. Ishikawa, H. Tanaka, C. Miron, T. Kondo, K. Nakamura, M. Mizuno, H. Kajiyama, S. Toyokuni, M. Hori

Organic decomposition and synthesis reactions in lactated solution exposed to nonequilibrium atmospheric pressure plasma

PlasmaProcessesandPolymers, 2023

6. Yasumasa Okazaki, Nanami Ito, Hiromasa Tanaka, Masaru Hori & Shinya Toyokuni

Non-thermal plasma elicits ferrous chloride-catalyzed DMPO-OH

, 2022

7. Y. Liu, Y. Nakatsu, H. Tanaka, K. Koga, K. Ishikawa, M. Shiratani, M. Hori

Effects of plasma-activated Ringer’s lactate solution on cancer cells: evaluation of genotoxicity

GenesandEnvironment, 45, 2023

8. Ryusei Sakai, Hiroki Kondo, Kenji Ishikawa, Takayuki Ohta, Mineo Hiramatsu, Hiromasa Tanaka and Masaru Hori

Effects of High-Quality Carbon Nanowalls Ionization-Assisting Substrates on Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Performance

Nanomaterials, 13, 63, 2022

9. Yoshihiro Sakamoto, Takayoshi Tsutsumi, Hiromasa Tanaka, Kenji Ishikawa, Hiroshi Hashizume, Masaru Hori

Indoor Floor Heel Mark Removal Using Spark Discharges and Pressurized Airflow

Coatings, 13, 2022

10. D. Onoshima, T. Hase, N. Kihara, D. Kuboyama, H. Tanaka, N. Ozawa, H. Yukawa, M. Sato, K. Ishikawa, Y. Hasegawa, M. Ishii, M. Hori, Y. Baba

Leukocyte Depletion and Size-Based Enrichment of Circulating Tumor Cells Using a Pressure-Sensing Microfiltration Device

ACSMeasurementScienceAu, 2022

11. Koki Ono, Takashi Koide, Kenji Ishikawa, Hiromasa Tanaka, Hiroki Kondo, Ayae Sugawara-Narutaki, Yong Jin, Shigeno Yasuhara, Masaru Hori and Wakana Takeuchi

Biocompatibility of conformal silicon carbide on carbon nanowall scaffolds

Jpn J Appl Phys, 62, SA1017, 2022

12. D. Ito, N. Iwata, K. Ishikawa, K. Nakamura, H. Hashizume, C. Miron, H. Tanaka, H. Kajiyama, S. Toyokuni, M. Mizuno, M. Hori

Cytotoxicity of plasma-irradiated lactate solution produced under atmospheric airtight conditions and generation of the methyl amino group

AppliedPhysicsExpress, 2022

2021年度

1. T. Ichikawa, K. Ishikawa, H. Tanaka, N. Shimizu, M. Hori

Scaffolds with isolated carbon nanowalls promote osteogenic differentiation through Runt-related transcription factor 2 and osteocalcin gene expression of osteoblast-like cells

AIPAdvances, 12, 12, 2022

2. Y. Okazaki, K. Sasaki, N. Ito, H. Tanaka, K.-I. Matsumoto, M. Hori, S. Toyokuni

Tetrachloroaurate (III)-induced oxidation increases non-thermal plasma-induced oxidative stress

FreeRadicalResearch, 2022

3. M. Laroussi, S. Bekeschus, M. Keidar, A. Bogaerts, A. Fridman, X.P. Lu, K.K. Ostrikov, M. Hori, K. Stapelmann, V. Miller, S. Reuter, C. Laux, A. Mesbah, J. Walsh, C. Jiang, S.M. Thagard, H. Tanaka, D.W. Liu, D. Yan, M. Yusupov

Low Temperature Plasma for Biology, Hygiene, and Medicine: Perspective and Roadmap

IEEETransactionsonRadiationandPlasmaMedicalSciences, 2022

4. H. Tanaka, M. Mizuno, K. Ishikawa, S. Toyokuni, H. Kajiyama, F. Kikkawa, M. Hori

Cancer Treatments Using Low-Temperature Plasma

Current Medicinal Chemistry, 28, , 2021

5. H. Tanaka, Y. Hosoi, K. Ishikawa, J. Yoshitake, T. Shibata, K. Uchida, H. Hashizume, M. Mizuno, Y. Okazaki, S. Toyokuni, K. Nakamura, H. Kajiyama, F. Kikkawa, M. Hori

Low temperature plasma irradiation products of sodium lactate solution that induce cell death on U251SP glioblastoma cells were identified

Sci Rep, 11, 18488, 2021

6. H. Tanaka, S. Matsumura, K. Ishikawa, H. Hashizume, M. Ito, K. Nakamura, H. Kajiyama, F. Kikkawa, M. Ito, K. Ohno, Y. Okazaki, S. Toyokuni, M. Mizuno, M. Hori

Enhancement of ethanol production and cell growth in budding yeast by direct irradiation of low-temperature plasma

Jpn J Appl Phys, 2021

7. H. Tanaka, S. Maeda, K. Nakamura, H. Hashizume, K. Ishikawa, M. Ito, K. Ohno, M. Mizuno, Y. Motooka, Y. Okazaki, S. Toyokuni, H. Kajiyama, F. Kikkawa, and M. Hori

Plasma-activated Ringer's lactate solution inhibits cellular respiratory system in HeLa cells

Plasma Process Polym, 18, e2100056, 2021

8. M. Yamato, Y. Tamura, H. Tanaka, K. Ishikawa, Y. Ikehara, M. Hori, Y. Kataoka

Brain cell proliferation in adult rats after irradiation with nonequilibrium atmospheric pressure plasma

Appl Phys Express, 14, 67002, 2021

9. L. Jiang, H. Zheng, Q. Lyu, S. Hayashi, K. Sato, Y. Sekido, K. Nakamura, H. Tanaka, K. Ishikawa, H. Kajiyama, M. Mizuno, M. Hori, S. Toyokuni

Lysosomal nitric oxide determines transition from autophagy to ferroptosis after exposure to plasma-activated Ringer's lactate

Redox biology, 43, 101989, 2021

10. Y. Okazaki, H. Tanaka, K.-I. Matsumoto, M. Hori, S. Toyokuni

Non-thermal plasma-induced DMPO-OH yields hydrogen peroxide

Archives of biochemistry and biophysics, 705, 108901, 2021

11. N.K. Kaushik, S. Bekeschus, H. Tanaka, A. Lin, E.H. Choi

Plasma Medicine Technologies

Applied Sciences, 11, 4584, 2021

2020年度

1. H. Tanaka, S. Bekeschus, D. Yan, M. Hori, M. Keidar, M. Laroussi

Plasma-Treated Solutions (PTS) in Cancer Therapy

Cancers, 13, 2021

2. K. Eto, C. Ishinada, T. Suemoto, K. Hyakutake, H. Tanaka, M. Hori

Differential data on the responsiveness of multiple cell types to cell death induced by non-thermal atmospheric pressure plasma-activated solutions

Data in Brief, 36, 2021

3. K. Nakamura, N. Yoshikawa, Y. Mizuno, M. Ito, H. Tanaka, M. Mizuno, S. Toyokuni, M. Hori, F. Kikkawa and H. Kajiyama

Preclinical Verification of the Efficacy and Safety of Aqueous Plasma for Ovarian Cancer Therapy

Cancers, 13, 1141, 2021

4. Ko Eto, Chiaki Ishinada, Takuya Suemoto, Keiichiro Hyakutake, Hiromasa Tanaka,Masaru Hori

A novel and distinctive mode of cell death revealed by using non-thermal atmospheric pressure plasma: The involvements of reactive oxygen species　and the translation inhibitor Pdcd4

Chemico-Biological Interactions, 228, 109403, 2021

5. Y. Okazaki, Y. Ishidzu, F. Ito, H. Tanaka, M. Hori, S. Toyokuni

L-Dehydroascorbate efficiently degrades non-thermal plasma-induced hydrogen peroxide

Archives of biochemistry and biophysics, 700, 108762, 2021

6. H. Hashizume, H. Kitano, H. Mizuno, A. Abe, G. Yuasa, S. Tohno, H. Tanaka, K. Ishikawa, S. Matsumoto, H. Sakakibara, S. Nikawa, M. Maeshima, M. Mizuno, M. Hori

Improvement of yield and grain quality by periodic cold plasma treatment with rice plants in a paddy field

Plasma Process Polym, 18, e2000181, 2020

7. P. Favia, E. Sardella, H. Tanaka

Special issue: Advanced applications of plasmas in Life Sciences 2020

Plasma Process Polym, 17, 2020

8. Y. Liu, K. Ishikawa, C. Miron, H. Hashizume, H.Tanaka, and M. Hori

Hydrogen peroxide in lactate solutions irradiated by non-equilibrium atmospheric pressure plasma

Plasma Sources Science and Technology, 30, , 2020

9. Y. Kurokawa, K. Takeda, K. Ishikawa, H. Tanaka and M. Hori

Laser-induced-plasma-activated medium enables killing of HeLa cells

Appl Phys Express, 13, 106001, 2020

5. K. Nakamura, N. Yoshikawa, M. Yoshihara, Y. Ikeda, A. Higashida, A. Niwa, T. Jindo, H. Tanaka, K. Ishikawa, M. Mizuno, S. Toyokuni, M. Hori, F. Kikkawa, and H. Kajiyama

Adjusted multiple gases in the plasma flow induces differential antitumor potentials of plasma-activated solutions

Plasma Processes and Polymers, 17, 2020

6. K. Ishikawa, Y. Hosoi, H. Tanaka, L. Jiang, S. Toyokuni, K. Nakamura, H. Kajiyama, F. Kikkawa, M. Mizuno, and M. Hori

Non-thermal plasma–activated lactate solution kills U251SP glioblastoma cells in an innate reductive manner with altered metabolism

Archives of Biochemistry and Biophysics, 688, 108414, 2020

7. N. Yoshikawa, W. Liu, K. Nakamura, K. Yoshida, Y. Ikeda, H. Tanaka, M. Mizuno, S. Toyokuni, M. Hori, F. Kikkawa, and H. Kajiyama

Plasma-activated medium promotes autophagic cell death along with alteration of the mTOR pathway

Sci Rep, 10, 1614, 2020

2019年度

1. H. Tanaka, M. Mizuno, Y. Katsumata, K. Ishikawa, H. Kondo, H. Hashizume, Y. Okazaki, S. Toyokuni, K. Nakamura, N. Yoshikawa, H. Kajiyama, F. Kikkawa, M. Hori

Oxidative stress-dependent and -independent death of glioblastoma cells induced by non-thermal plasma-exposed solutions

Sci Rep, 9, 13657, 2019

2. Y. Okazaki, H. Tanaka, M. Hori, S. Toyokuni

L-Dehydroascorbic acid recycled by thiols efficiently scavenges non-thermal plasma-induced hydroxyl radicals

Archives of biochemistry and biophysics, 669, 87～95, 2019

3. T. Ichikawa, H. Kondo, K. Ishikawa, T. Tsutsumi, H. Tanaka, M. Sekine, M. Hori

Gene expression of osteoblast-like cells on carbon-nanowall as scaffolds during incubation with electrical stimulation

ACS Applied Materials, 2, 2698～2702, 2019

4. S. Yamaoka, H. Kondo, H. Hashizume, K. Ishikawa, H. Tanaka, M. Hori,

Plasma-activated solution alters the morphological dynamics of supported lipid bilayers observed by high-speed atomic force microscopy

Appl Phys Express, 12, 66001, 2019

5. K. Sato, L. Shi, F. Ito, Y. Ohara, Y. Motooka, H. Tanaka, M. Mizuno, M. Hori, T. Hirayama, S. Hibi, S. Toyokuni,

Non-thermal plasma specifically kills oral squamous cell carcinoma cells in a catalytic F2(II)-dependent manner

Journal of Clinical Biochemistry and Nutrition, 65, 8～15 , 2019

2018年度

1. N. Kurake, K. Ishikawa, H. Tanaka, H. Hashizume, K. Nakamura, H. Kajiyama, S. Toyokuni, F. Kikkawa, M. Mizuno, M. Hori

Non-thermal plasma-activated medium modified metabolomic profiles in the glycolysis of U251SP glioblastoma

Archives of biochemistry and biophysics, 662, 83～92, 2019

2. T.R. Brubaker, K. Ishikawa, H. Kondo, T. Tsutsumi, H. Hashizume, H. Tanaka, S.D. Knecht, S.G. Bilen, M. Hori

Liquid dynamics in response to an impinging low-temperature plasma jet

J Phys D Appl Phys, 52, 75203, 2019

3. K. Niitsu, T. Nakanishi, S. Murakami, M. Matsunaga, A. Kobayashi, N.M. Karim, J. Ito, N. Ozawa, T. Hase, H. Tanaka, M. Sato, K. Hiroki, K. Ishikawa, H. Odaka, Y. Hasegawa, M. Hori, K. Nakazato

A 65-nm CMOS Fully-Integrated Analysis Platform Using an On-Chip Vector Network Analyzer and a Transmission-Line-Based Detection Window for Analyzing Circulating Tumor Cell and Exosome

IEEE transactions on biomedical circuits and systems, 13, 470～479, 2018

4. H. Tanaka, M. Mizuno, K. Ishikawa, S. Toyokuni, H. Kajiyama, F. Kikkawa, M. Hori

Molecular mechanisms of non-thermal plasma-induced effects in cancer cells

Biological chemistry, 400, 87～91, 2018

5. H. Tanaka, M. Mizuno, K. Ishikawa, S. Toyokuni, H. Kajiyama, F. Kikkawa, M. Hori

New hopes for plasma-based cancer treatment

Plasma, 1, 150～155, 2018

6. D. Kanno, H. Tanaka, K. Ishikawa, H. Hashizume, M. Hori

Cytotoxic effects of plasma-irradiated fullerenol

J Phys D Appl Phys, 51, 375401, 2018

2017年度

1. N. Kihara, D. Kuboyama, D. Onoshima, K. Ishikawa, H. Tanaka, N. Ozawa, T. Hase, R. Koguchi, H. Yukawa, H. Odaka, Y. Hasegawa, Y. Baba, M. Hori

Low-autofluorescence fluoropolymer membrane filters for cell filtration

Jpn J Appl Phys, 57, 06JF03, 2018

2. H.R. Metelmann, C. Seebauer, V. Miller, A. Fridman, G. Bauer, D.B. Graves, J.M. Pouvesle, R. Rutkowski, M. Schuster, S. Bekeschus, K. Wende, K. Masur, S. Hasse, T. Gerling, M. Hori, H. Tanaka, E. Choi, K.D. Weltemann, T. von Woedtke

Clinical experience with cold plasma in the treatment of locally advanced head and neck cancer

Clinical Plasma Medicine, 9, 6～13, 2018

3. Y. Takahashi, Y. Taki, K. Takeda, H. Hashizume, H. Tanaka, K. Ishikawa, M. Hori

Cytotoxicity of cancer HeLa cells sensitivity to normal MCF10A cells in cultivations with cell culture medium treated by microwave-excited atmospheric pressure plasmas

Journal of Physics D: Applied Physics, 51, 115401, 2018

4. Y. Takahashi, Y. Taki, K. Takeda, H. Hashizume, H. Tanaka, K. Ishikawa, M. Hori

Reduced HeLa cell viability in methionine-containing cell culture medium irradiated with microwave-excited atmospheric-pressure plasma

Plasma Processes and Polymers, 15, e1700200, 2018

5. Y. Sato, S. Yamada, S. Takeda, N. Hattori, K. Nakamura, H. Tanaka, M. Mizuno, M. Hori, Y. Kodera

Effect of Plasma-Activated Lactated Ringer's Solution on Pancreatic Cancer Cells In Vitro and In Vivo

Annals of surgical oncology, 25, 299～307 , 2018

6. J.I. Ikeda, H. Tanaka, K. Ishikawa, H. Sakakita, Y. Ikehara, M. Hori

Plasma-activated medium (PAM) kills human cancer-initiating cells

Pathology international, 68, 23～30 , 2018

7. H. Tanaka, M. Mizuno, K. Ishikawa, K. Takeda, H. Hashizume, K. Nakamura, F. Utsumi, H. Kajiyama, Y. Okazaki, S. Toyokuni, S. Akiyama, S. Maruyama, F. Kikkawa, M. Hori

Glioblastoma cell lines display different sensitivities to plasma-activated medium

IEEE Transactions on Radiation and Plasma Medical Sciences, 2, 99～102 , 2017

8. T.R. Brubaker, K. Ishikawa, K. Takeda, J.S. Oh, H. Kondo, H. Hashizume, H. Tanaka, S.D. Knecht, S.G. Bilen, M. Hori

Dynamic analysis of reactive oxygen nitrogen species in plasma-activated culture medium by UV absorption spectroscopy

Journal of Applied Physics, 122, 213301, 2017

9. N. Kurake, H. Tanaka, K. Ishikawa, K. Nakamura, H. Kajiyama, F. Kikkawa, M. Mizuno, Y. Ikehara, M. Hori

Crystallization of calcium oxalate dihydrate in a buffered calcium-containing glucose solution by irradiation with non-equilibrium atmospheric pressure plasma

Journal of Applied Physics, 122, 143301, 2017

10. R. Furuta, N. Kurake, K. Ishikawa, K. Takeda, H. Hashizume, H. Tanaka, H. Kondo, M. Sekine, M. Hori

Intracellular responses to reactive oxygen and nitrogen species, and lipid peroxidation in apoptotic cells cultivated in plasma-activated medium

Plasma Processes and Polymers, 14, e1700123 , 2017

11. R. Furuta, N. Kurake, K. Takeda, K. Ishikawa, T. Ohta, M. Ito, H. Hashizume, H. Tanaka, H. Kondo, M. Sekine, M. Hori

Lipid droplets exhaustion with caspases activation in HeLa cells cultured in plasma-activated medium observed by multiplex coherent anti-Stokes Raman scattering microscopy

Biointerphases, 12, 31006, 2017

12. K. Nakamura, Y. Peng, F. Utsumi, H. Tanaka, M. Mizuno, S. Toyokuni, M. Hori, F. Kikkawa, H. Kajiyama

Novel Intraperitoneal Treatment With Non-Thermal Plasma-Activated Medium Inhibits Metastatic Potential of Ovarian Cancer Cells

Scientific Reports, 7, 6085, 2017

13. H. Tanaka, K. Ishikawa, M. Mizuno, S. Toyokuni, H. Kajiyama, F. Kikkawa, H.R. Metelmann, M. Hori

State of the art in medical applications using non-thermal atmospheric pressure plasma

Reviews of Modern Plasma Physics, 1:3, 1～89, 2017

14. L. Shi, F. Ito, Y. Wang, Y. Okazaki, H. Tanaka, M. Mizuno, M. Hori, T. Hirayama, H. Nagasawa, D.R. Richardson, S. Toyokuni

Non-thermal plasma induces a stress response in mesothelioma cells resulting in increased endocytosis, lysosome biogenesis and autophagy

Free radical biology & medicine, 108, 904-917 , 2017

15. N. Wada, J.I. Ikeda, H. Tanaka, H. Sakakita, M. Hori, Y. Ikehara, E. Morii

Effect of plasma-activated medium on the decrease of tumorigenic population in lymphoma

Pathology research and practice, 213, 773～777 , 2017

2016年度

1. K. Takeda, K. Ishikawa, H. Tanaka, M. Sekine, M. Hori

Spatial distributions of O, N, NO, OH and vacuum ultraviolet light along gas flow direction in an AC-excited atmospheric pressure Ar plasma jet generated in open air

Journal of Physics D: Applied Physics, 50, 195202, 2017

2. N. Kurake, H. Tanaka, K. Ishikawa, K. Takeda, H. Hashizume, K. Nakamura, H. Kajiyama, T. Kondo, F. Kikkawa, M. Mizuno, M. Hori

Effects of •OH and •NO radicals in the aqueous phase on H2O2 and NO2- generated in plasma-activated medium

Journal of Physics D: Applied Physics, 50, 155202, 2017

3. K. Takeda, T. Kumakura, K. Ishikawa, H. Tanaka, M. Sekine, M. Hori

Behavior of absolute densities of atomic oxygen in the gas phase near an object surface in an AC-excited atmospheric pressure He plasma jet

Applied Physics Express, 10, 36201, 2017

4. S. Takeda, S. Yamada, N. Hattori, K. Nakamura, H. Tanaka, H. Kajiyama, M. Kanda, D. Kobayashi, C. Tanaka, T. Fujii, M. Fujiwara, M. Mizuno, M. Hori, Y. Kodera

Intraperitoneal Administration of Plasma-Activated Medium: Proposal of a Novel Treatment Option for Peritoneal Metastasis From Gastric Cancer

Annals of surgical oncology, 24, 1188～1194 , 2017

5. H. Kajiyama, F. Utsumi, K. Nakamura, H. Tanaka, S. Toyokuni, M. Hori, F. Kikkawa

Future perspective of strategic non-thermal plasma therapy for cancer treatment

, 60, 33～38 , 2017

6. H. Tanaka, M. Hori

Medical applications of non-thermal atmospheric pressure plasma

Journal of Clinical Biochemistry and Nutrition, 60, 29～32 , 2017

7. H. Tanaka, K. Nakamura, M. Mizuno, K. Ishikawa, K. Takeda, H. Kajiyama, F. Utsumi, F. Kikkawa, M. Hori

Non-thermal atmospheric pressure plasma activates lactate in Ringer’s solution for anti-tumor effects

Scientific Reports, 6, 36282, 2016

8. R. Matsumoto, K. Shimizu, T. Nagashima, H. Tanaka, M. Mizuno, F. Kikkawa, M. Hori, H. Honda

Plasma-Activated Medium Selectively Eliminates Undifferentiated Human Induced Pluripotent Stem Cells

Regenerative Therapy, 5, 55～63 , 2016

9. N. Kurake, H. Tanaka, K. Ishikawa, K. Nakamura, H. Kajiyama, F. Kikkawa, M. Mizuno, Y. Yamanishi, M. Hori

Synthesis of calcium oxalate crystals in culture medium irradiated with non-equilibrium atmospheric-pressure plasma Authors

Applied Physics Express, 9, 96201, 2016

10. C. Ishida, M. Mori, K. Nakamura, H. Tanaka, M. Mizuno, M. Hori, A. Iwase, F. Kikkawa and S. Toyokuni

Non-thermal plasma prevents progression of endometriosis in mice

Free Radical Research, 50, 1131～1139 , 2016

11. T. Ito, K. Ishikawa, D. Onoshima, N. Kihara, K. Tatsukoshi, H. Odaka, H. Hashizume, H. Tanaka, H. Yukawa, K. Takeda, H. Kondo, M. Sekine, Y. Baba, and M. Hori

Microfluidic Transport Through Microsized Holes Treated by Nonequilibrium Atmospheric-Pressure Plasma

IEEE Transactions on Plasma Science, 44, 1～6 , 2016

12. L. Shi, Y. Wang, F. Ito, Y. Okazaki, H. Tanaka, M. Mizuno, M. Hori, D.R. Richardson, S. Toyokuni

Biphasic effects of L-ascorbate on the tumoricidal activity of non-thermal plasma against malignant mesothelioma cells

Archives of Biochemistry and Biophysics, 605, 109～116 , 2016

13. F. Utsumi, H. Kajiyama, K. Nakamura, H. Tanaka, M. Mizuno, S. Toyokuni, M. Hori, and F. Kikkawa

Variable susceptibility of ovarian cancer cells to non-thermal plasma-activated medium

Oncology Reports, 35, 3169～3177 , 2016

2015年度

1. N. Kurake, H. Tanaka, K. Ishikawa, T. Kondo, M. Sekine, K. Nakamura, H. Kajiyama, F. Kikkawa, M. Mizuno, and M. Hori

Cell survival of glioblastoma grown in medium containing hydrogen peroxide and/or nitrite, or in plasma-activated medium

Archives of Biochemistry and Biophysics, 605, 102～108 , 2016

2. H. Tanaka, M. Mizuno, F. Kikkawa, and M. Hori

Interactions between a Plasma-activated medium and Cancer Cells

Plasma Medicine, 6, 101～106 , 2016

3. H. Kajiyama, F. Utsumi, K. Nakamura, H. Tanaka, M. Mizuno, S. Toyokuni, M. Hori, and F. Kikkawa

Possible therapeutic option of aqueous plasma for refractory ovarian cancer

Clinical Plasma Medicine, 4, 14～18 , 2016

4. H. Tanaka, M. Mizuno, S. Toyokuni, S. Maruyama, Y. Kodera, H. Terasaki, T. Adachi, M. Kato, F. Kikkawa, and M. Hori

Cancer therapy using non-thermal atmospheric pressure plasma with ultra-high electron density

Physics of Plasmas, 22, 122004, 2015

5. H. Tanaka, M. Mizuno, K. Ishikawa, H. Kondo, K. Takeda, H. Hashizume, K. Nakamura, F. Utsumi, H. Kajiyama, H. Kano, Y. Okazaki, S. Toyokuni, S. Akiyama, S. Maruyama, S. Yamada, Y. Kodera, H. Kaneko, H. Terasaki, H. Hara, T. Adachi, M. Iida, I. Yajima, M. Kato, F. Kikkawa, and M. Hori

Plasma with high electron density and Plasma-Activated Medium for Cancer Treatment

Clinical Plasma Medicine, 3, 72～76 , 2015

6. N. Hattori, S. Yamada, K. Torii, S. Takeda, K. Nakamura, H. Tanaka, H. Kajiyama, M. Kanda, T. Fujii, G. Nakayama, H. Sugimoto, M. Koike, S. Nomoto, M. Fujiwara, M. Mizuno, M. Hori, Y. Kodera

Effectiveness of plasma treatment on pancreatic cancer cells

International Journal of Oncology, 47, 1655～1662 , 2015

2014年度

1. F. Ye, H. Kaneko, Y. Nagasaka, R. Ijima, K. Nakamura, M. Nagaya, K. Takayama, H. Kajiyama, T. Senga, H. Tanaka, M. Mizuno, F. Kikkawa, M. Hori, H. Terasaki

Plasma-activated medium suppresses choroidal neovascularization in mice: a new therapeutic concept for age-related macular degeneration

Scientific Reports, 5, 7705, 2015

2. T. Adachi, H. Tanaka, S. Nonomura, H. Hara, S. I. Kondo, and M. Hori

Plasma-activated medium-induced A549 cell injury by a spiral apoptotic cascade involving the mitochondrial-nuclear network and plasma membrane

Free Radical Biology & Medicine, 79, 28～44 , 2015

3. H. Tanaka, M. Mizuno, K. Ishikawa, K. Nakamura, F. Utsumi, H. Kajiyama, H. Kano, Y. Okazaki, S. Toyokuni, S. Maruyama, F. Kikkawa, M. Hori

Plasma Medical Science for Cancer Therapy ~toward cancer therapy using non-thermal atmospheric pressure plasma ~

IEEE Transactions on Plasma Science, 42, 3760～3763 , 2014

4. Y. Okazaki, Y. Wang, H. Tanaka, M. Mizuno, K. Nakamura, H. Kajiyama, H. Kano, K. Uchida, F. Kikkawa, M. Hori, S. Toyokuni

Direct exposure of non-equilibrium atmospheric pressure plasma confers simultaneous oxidative and ultraviolet modifications in biomolecules

Journal of Clinical Biochemistry and Nutrition, 55, 207～215 , 2014

5. F. Utsumi, H. Kajiyama, K. Nakamura, H. Tanaka, M. Mizuno, K. Ishikawa, H. Kondo, H. Kano, M. Hori, F. Kikkawa

Selective cytotoxicity of indirect nonequilibrium atmospheric pressure plasma against ovarian clear-cell carcinoma

Springerplus, 6, 398, 2014

6. K. Torii, S. Yamada, K. Nakamura, H. Tanaka, H. Kajiyama, K. Tanahashi, N. Iwata, M. Kanda, D. Kobayashi, C. Tanaka, T. Fujii, G. Nakayama, M. Koike, H. Sugimoto, S. Nomoto, A. Natsume, M. Fujiwara, M. Mizuno, M. Hori, H.Saya, Y. Kodera

Effectiveness of plasma treatment on gastric cancer cells

Gastric Cancer, 18, 635～643, 2014

7. H. Tanaka, M. Mizuno, K. Ishikawa, K. Nakamura, F. Utsumi, H. Kajiyama, H. Kano, S. Maruyama, F. Kikkawa, M. Hori

Cell survival and proliferation signaling pathways are downregulated by plasma-activated medium in glioblastoma brain tumor cells

Plasma Medicine, 2, 207～220, 2014

7. H. Kajiyama, K. Nakamura, F. Utsumi, H. Tanaka, M. Hori, and F. Kikkawa

Perspective of strategic plasma therapy in patients with epithelial ovarian cancer: A short review of plasma in cancer treatment

Japanese Journal of Applied Physics, 53, 05FA05, 2014

2013年度

1. F. Utsumi, H. Kajiyama, K. Nakamura, H. Tanaka, M. Mizuno, K. Ishikawa, H. Kondo, H. Kano, M. Hori, F. Kikkawa

Effect of Indirect Nonequilibrium Atmospheric Pressure Plasma on Anti-Proliferative Activity against Chronic Chemo-Resistant Ovarian Cancer Cells In Vitro and In Vivo

PLoS ONE, 8, e81576, 2013

2. F.J. Vizeacoumar, R. Arnold, F.S. Vizeacoumar, M. Chandrashekhar, A. Buzina, J.T. Young, J.H. Kwan, A. Sayad, P. Mero, S. Lawo, H. Tanaka, K.R. Brown, A. Baryshnikova, A.B. Mak, Y. Fedyshyn, Y. Wang, G.C. Brito, D. Kasimer, T. Makhnevych, T. Ketela, A. Datti, M. Babu, A. Emili, L. Pelletier, J. Wrana, Z. Wainberg, P.M. Kim, R. Rottapel, C.A. O'Brien, B. Andrews, C. Boone, J. Moffat

A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities

Molecular Systems Biology, 9, 696, 2013

3. T.I. Moore, H. Tanaka, H.J. Kim, N.L. Jeon, T.M. Yi

Yeast G-proteins mediate directional sensing and polarization behaviors in response to changes in pheromone gradient direction

Molecular Biology of the Cell, 24, 521～534, 2013